Positive Association between Macular Pigment Optical Density and Glomerular Filtration Rate: A Cross-Sectional Study

Although decreased macular pigment density is associated with the development of age-related degeneration (AMD), exactly how this decrease may contribute to AMD still not fully understood. In study, we investigated relationship between optical (MPOD) and estimated glomerular filtration rate (eGFR). MPOD was measured using MPS II (Electron Technology, Cambridge, UK) in 137 participants who showed no clinical signs at 3 months after cataract surgery, simple multiple linear regression analyses were performed determine associations age, sex, abdominal circumference, diabetes, hypertension, smoking, intraocular lens color, visual acuity before eGFR. The divided into two groups based on median (0.58): high-pigment low-pigment groups. mean value eGFR group significantly higher than that (64.2 vs. 58.1, p = 0.02). analysis revealed a significant positive association (β 0.0034, 95% confidence interval [CI]: 0.0011–0.0056, 0.0038), independent best-corrected (BCVA) BCVA color 0.0033, CI: 0.00090–0.0058, 0.0076). These results show strong renal dysfunction MPOD.